Inhibitors of thrombin and factor Xa. Factor Xa interacts with factor Va to convert prothrombin into thrombin. Besides their activity in coagulation, factor Xa and thrombin can signal through activation of PAR1 and PAR2 by proteolytic cleavage of a distinct N-terminal cleavage site in these receptors, which generates a new bound peptide that acts as a tethered signal-inducing ligand in an

The most important positive effects of statins are anti-inflammatory, anti-proliferative, antioxidant, immunomodulatory, neuroprotective, anti-diabetes, and antithrombotic, improving endothelial dysfunction and attenuating vascular remodeling besides many others which are discussed under the scope of this review.

Dronedarone is an antiarrhythmic drug for the maintenance of sinus Pleiotropic Effects of Resistance-Breaking Mutations on Particle Stability Provide Insight into Life History Evolution of a Plant RNA Virus. Sayanta Bera, Manuel There were shown also to exist non-lipid-modifiable effects of statins called pleiotropic ones, which could be responsible for this additional benefit. The most The effects of deleting the QA motif were strong in some tissues but barely detectable in others. This finding of differential pleiotropy suggests that peptide motifs Pleiotropy refers to the phenomenon by which a gene pair at a single locus affects many (more than one) phenotype characteristics.

Pleiotropic effects

However, the overall clinical benefits observed with statin therapy appear to be greater than what might be expected from changes in lipid profile alone, suggesting that the beneficial effects of statins may extend beyond their effects on serum cholesterol levels. Clusters of QTL for plant source capacity and seed traits may correspond to genes of metabolism having pleiotropic effects on source-sink relationships. When expressed during seed set, these genes may control the seed number and the NcotCel. When expressed during seed growth, they may control seed weight or seed protein content. Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease Vinicius M. Fava , Yong Zhong Xu , Guillaume Lettre , Nguyen Van Thuc , Marianna Orlova , Vu Hong Thai , Shao Tao , Nathalie Croteau , Mohamed A. Eldeeb , Emma J. MacDougall , Geison Cambri , Ramanuj Lahiri , Linda Adams , Edward A. Fon , Jean-François Trempe , Aurélie Cobat , Alexandre Alcaïs 2019-07-11 · Chickens with this particular mutated feather gene display feathers that curl outward as opposed to lying flat. In addition to curled feathers, other pleiotropic effects include a faster metabolism and enlarged organs.

Most of the effects of statins can be explained by pleiotropic effects independent of their lowering of serum cholesterol; in some cases, these effects have been shown to be a result of the role lowering effects, to include so-called pleiotropic effects. These cholesterol-independent effects include improving endothelial function, attenuating vascular and myocardial remodeling, inhibiting vascular inflammationand oxida-tion, and stabilizing atherosclerotic plaques.

Many of these pleiotropic effects are mediated by inhibition of isoprenoids, which serve as lipid attachments for intracellular signaling molecules. In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the pleiotropic effects of statins.

Purpose A step-up strategy for diet therapy and/or single oral antihyperglycemic agent (OHA) regimens has not yet been established. The aim of this study was to evaluate hemoglobin A1c (HbA1c) as a primary end point, and the pleiotropic effects on metabolic and cardiovascular parameters as secondary end points, of sitagliptin versus voglibose in patients with type 2 diabetes with inadequate Jan 23, 2020 Genetic effects of the same locus on multiple traits, termed pleiotropic effects, are widespread in natural systems ranging from bacteria to humans Indeed, recent studies indicate that some of the cholesterol-independent or “ pleiotropic” effects of statins involve improving endothelial function, enhancing the Pleiotropic definition is - producing more than one effect; especially : having multiple phenotypic expressions. How to use pleiotropic in a sentence. Nov 19, 2018 Statins exerts their pleiotropic effects by hindering the conversion of HMG-CoA to L-mevalonic corrosive, statins keep the union of imperative Aug 25, 2020 Multivariable Mendelian randomization estimates for effects of genetically mimicked statins (effect sizes of LDL-cholesterol) and of testosterone ( Jan 28, 2021 We also evaluated the effect of short-term GOS feeding on how the aging gut microbiome responds to antibiotic challenges, since these Official Title: A Multicenter, Randomized Double-Blind Study Comparing The Pleiotropic Effects Of Atorvastatin 10 Mg And 80 Mg Over A 26-Week Period In May 1, 2019 Pleiotropic genes are genes that affect more than one trait.

Statins could be one of those due to their pleiotropic effects on inflammation and fibrosis, in addition to the antihyperlipidemic effect they are used more commonly for. Statins Pleiotropy. Statins, 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, are primarily used for primary and secondary prevention of coronary heart disease.

3. Thus, it is not surprising that mutations in genes which function in melanocyte development or melanogenesis frequently cause pleiotropic effects involving sight, hearing and neurologic functioning. Many pleiotropic effects recently studied in mice have come from investigating mutagenesis screens and knockout mutations.

Good overview of pleiotropic effects. Statins may have good effects for Alzheimer's and Parkinson's disease, infection management, and traumatic brain injury and spinal cord injury. 2015-12-08 2002-04-01 Recent experimental evidence supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability). 2021-01-28 the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen.
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1,2 They include increases in endothelial nitric oxide formation; flow-mediated vascular dilatation; suppression of vascular inflammation; reduction of circulating biomarkers that indicate inflammation (such as C-reactive protein); a reduction in T-cell activation with a decrease in cytokines; promotion of neovascularization in ischemic tissue; and … Statins may exert cardiovascular protective effects that are independent of LDL-cholesterol lowering called pleiotropic effects.

High cholesterol is a risk factor for Arthritis Risk.
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Signaling is initiated by ligand-specific activation of cell surface receptors with intrinsic tyrosine kinase activity. In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects which are detrimental ones, but is often used to denote additional beneficial effects. The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and Pluripotency. de Jaime-Soguero A(1), Abreu de Oliveira WA(2), Lluis F(3). Author information: (1)Stem Cell Signalling Laboratory, Department of Development and Regeneration, KU Leuven Stem Cell Institute, Herestraat 49, Onderwijs en Navorsing 4, Box 804, 3000 Leuven Pleiotropic: Producing or having multiple effects from a single gene.